Taltobulin trifluoroacetate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$900	To Be Confirmed
100mg	$1350	To Be Confirmed
200mg	$2025	To Be Confirmed

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Cat #: V31385 CAS #: 228266-41-9 Purity ≥ 99%

Description: Taltobulin trifluoroacetate (HTI-286; HTI286; SPA-110; SPA110), the trifluoroacetate salt of taltobulin, is an nalogue of Hemiasterlin, acting as a tubulin inhibitor and used as an ADC cytotoxin (warhead).

References: Loganzo F, et al. HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res. 2003 Apr 15;63(8):1838-45.

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Physicochemical and Storage Information
Protocol
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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	587.67
Molecular Formula	C29H44F3N3O6
CAS No.	228266-41-9

Protocol	In Vitro	Taltobulin (HTI-286; 0.2-7.3 nM; 3 days) inhibits the growth of 18 tumor cell lines (leukemia, ovarian, NSCLC, breast, colon, and melanoma cell lines) with an average IC50 of 2.5±2.1 nM and a median value of 1.7 nM
	In Vivo	Taltobulin (HTI-286; 1.6 mg/kg i.v.) inhibits the growth of human tumor xenografts (e.g., HCT-15, DLD-1, MX-1W, and KB-8-5) in athymic nu/nu female mice
	Animal model	Athymic nu/nu female mice with Lox melanoma model (5-6 weeks of age)
	Dosages	1.6 mg/kg
	Administration	Administered i.v.;for 35 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7016 mL	8.5082 mL	17.0164 mL	34.0327 mL
5mM	0.3403 mL	1.7016 mL	3.4033 mL	6.8065 mL
10mM	0.1702 mL	0.8508 mL	1.7016 mL	3.4033 mL
20mM	0.0851 mL	0.4254 mL	0.8508 mL	1.7016 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.