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Demecolcine

This product is for research use only, not for human use. We do not sell to patients.

Demecolcine
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$750To Be Confirmed
100mg$1125To Be Confirmed
200mg$1685To Be Confirmed
email: [email protected]        [email protected]

Cat #: V19560 CAS #: 477-30-5 Purity ≥ 99%

Description: Demecolcine (Colcemid), a colchicine analog, is a potent microtubule polymerization inhibitor / mitotic inhibitor /depolymerizing anti-tubulin agent with anticancer activity.

References: T Tsuchida, et al. Colcemid-induced apoptosis of cultured human glioma: electron microscopic and confocal laser microscopic observation of cells sorted in different phases of cell cycle. Cytometry. 1998 Apr 1;31(4):295-9.

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Molecular Weight (MW)371.43
Molecular FormulaC21H25NO5
CAS No.477-30-5
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6923 mL13.4615 mL26.9230 mL53.8459 mL
5mM0.5385 mL2.6923 mL5.3846 mL10.7692 mL
10mM0.2692 mL1.3461 mL2.6923 mL5.3846 mL
20mM0.1346 mL0.6731 mL1.3461 mL2.6923 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.