NSC-23766 3HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
250mg	$750	Check With Us
500mg	$1250	Check With Us
1g	$1875	Check With Us

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Cat #: V0012 CAS #: 1177865-17-6 Purity ≥ 99%

Description: NSC23766 3HCl, the salt form of NSC23766, is a novel and potent inhibitor of Rac GTPase, it targets the Rac activation by guanine nucleotide exchange factors (GEFs) with an IC50 of ~50 μM in a cell-free assay; NSC23766 does not inhibit Cdc42 or RhoA, the closely related targets.

References: Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016;39(2):760-7.

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Physicochemical and Storage Information
Protocol
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Stock Solution Preparation
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Molecular Weight (MW)	530.96
Molecular Formula	C24H35N7.3HCl
CAS No.	1177865-17-6
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 100 mg/mL (188.3 mM)r
	Water: <1 mg/mLr
	Ethanol: 100 mg/mL (188.3 mM)
Synonyms	NSC-23766 3HCl; NSC-23766 3Hydrochloride; NSC23766; NSC-23766; NSC 23766

Protocol	In Vivo	NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8834 mL	9.4169 mL	18.8338 mL	37.6676 mL
5mM	0.3767 mL	1.8834 mL	3.7668 mL	7.5335 mL
10mM	0.1883 mL	0.9417 mL	1.8834 mL	3.7668 mL
20mM	0.0942 mL	0.4708 mL	0.9417 mL	1.8834 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.