1A-116 is a novel and potent specific Rac1 inhibitor

ML141 (also called CID-2950007; ML-141; CID2950007; ML 141) is a novel potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with potential anticancer activity.

Azathioprine (BW-57322; BW 57-322; Imuran; Azasan; Imurel; AZA; AZTP) is an approved immunosuppressive drug (prodrug of 6-MP) used in the treatment of organ transplantation and autoimmune diseases.

NSC23766 3HCl, the salt form of NSC23766, is a novel and potent inhibitor of Rac GTPase, it targets the Rac activation by guanine nucleotide exchange factors (GEFs) with an IC50 of ~50 μM in a cell-free assay; NSC23766 does not inhibit Cdc42 or RhoA, the closely related targets.

SAR407899 HCl is a novel, potent, selective, and ATP-competitive ROCK inhibitor with an IC50 of 135 nM for ROCK-2, and Kis of 36 nM and 41 nM for human and rat ROCK-2, respectively.

ZCL278 (ZCL-278; ZCL 278) is a potent, cell-permeable and selective Cdc42 GTPase inhibitor with potential anticancer activity.

CCG-222740 (CCG222740) is a novel and potent Rho/myocardin-related transcription factor (MRTF)/SRF inhibitor.

EHop-016 (EHOP016; EHop 016) is a novel, potent and selective small molecule inhibitor of Rac GTPase with potential antineoplastic activity.

CASIN is a novel, potent and selective inhibitor of Cdc42 GTPase, a small GTPase of the Rho-subfamily that plays important roles in cytoskeleton organization, cell cycle progression, signal transduction, and vesicle trafficking.

K-Ras(G12C) inhibitor 9 is a novel, covalent and allosteric inhibitor of K-RAS G12C mutant with potential anticancer activity.