CCG-1423
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $450 | Check With Us |
| 500mg | $750 | Check With Us |
| 1g | $1125 | Check With Us |
: Cat #: V1567 CAS #: 285986-88-1 Purity ≥ 98%
Description: CCG-1423 (CCG1423; CCG 1423) is a novel, potent and specific small-molecule inhibitor of RhoA signaling pathway with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 454.75 |
|---|---|
| Molecular Formula | C18H13ClF6N2O3 |
| CAS No. | 285986-88-1 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 90 mg/mL (197.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 4 mg/mL (8.8 mM) | |
| Synonyms | CCG1423; CCG-1423; CCG 1423 |
| Protocol | In Vitro | CCG-1423 (0-100 µM; 24 h) inhibits RhoA and RhoC signaling pathways with an IC50 value of 1.5 µM for Rho-pathway selective serum response element-luciferase reporter |
|---|---|---|
| In Vivo | CCG-1423 (0.15 mg/kg; i.p. once daily for two weeks) affects glucose tolerance and insulin levels in HFD-fed mice | |
| Animal model | 16-week-old mice with HFD-induced obesity | |
| Dosages | 0.15 mg/kg | |
| Administration | Intraperitoneal injection; 0.15 mg/kg once per day; for two weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1990 mL | 10.9951 mL | 21.9901 mL | 43.9802 mL |
| 5mM | 0.4398 mL | 2.1990 mL | 4.3980 mL | 8.7960 mL |
| 10mM | 0.2199 mL | 1.0995 mL | 2.1990 mL | 4.3980 mL |
| 20mM | 0.1100 mL | 0.5498 mL | 1.0995 mL | 2.1990 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.