SRI-011381
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V4080 CAS #: 1629138-41-5 Purity ≥ 98%
Description: SRI-011381 (SRI011381) is a novel and potent agonist of the TGF-beta signaling pathway with the potential for treatment of Alzheimer's disease.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 329.48 |
|---|---|
| Molecular Formula | C20H31N3O |
| CAS No. | 1629138-41-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 30mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(NC1CCCCC1)N(CC2=CC=CC=C2)CC3CCNCC3 |
| Synonyms | SRI011381; SRI 011381; SRI-011381 |
| Protocol | In Vivo | SRI-011381 (30 mg/kg； intraperitoneal injection; Every 2 days; For 22 days) Partial repair of optic nerve and retinal defects in YAPGFAP-CKO EAE mice |
|---|---|---|
| Animal model | YAPGFAP-CKO mice bearing experimental autoimmune encephalomyelitis (EAE) | |
| Dosages | 30 mg/kg | |
| Administration | Intraperitoneally injection; every 2 d; for 22 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.0351 mL | 15.1754 mL | 30.3509 mL | 60.7017 mL |
| 5mM | 0.6070 mL | 3.0351 mL | 6.0702 mL | 12.1403 mL |
| 10mM | 0.3035 mL | 1.5175 mL | 3.0351 mL | 6.0702 mL |
| 20mM | 0.1518 mL | 0.7588 mL | 1.5175 mL | 3.0351 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.