TP0427736 is a novel, potent and selective inhibitor of ALK5 kinase with IC50 value of 2.72 nM and appropriate in vitro and in vivo profiles.

LDN193189 2HCl is the dihydrochloride salt of LDN193189, which is a highly potent and selective small molecule inhibitor of the BMP (bone morphogenetic protein ) signaling pathway.

SIS3 is a potent and selective inhibitor of Smad3 function.

SIS3 HCl is a potent and selective inhibitor of Smad3 which is a receptor-regulated intracellular protein that functions downstream of TGF-β and activin receptors and mediates their signaling, playing a role in cell proliferation, differentiation, apoptosis and formation of extracellular matrix.

Oxymatrine (also known as Matrine N-oxide) is a naturally occuring quinolizidine alkaloid isolated from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases such as colpitis, psoriasis and eczema etc.

SRI-011381 (SRI011381) is a novel and potent agonist of the TGF-beta signaling pathway with the potential for treatment of Alzheimer’s disease.