Oxymatrine (Matrine N-oxide)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$199	Check With Us
2g	$290	Check With Us
5g	$460	Check With Us

: [email protected] [email protected]

Cat #: V2022 CAS #: 16837-52-8 Purity ≥ 98%

Description: Oxymatrine (also known as Matrine N-oxide) is a naturally occuring quinolizidine alkaloid isolated from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases such as colpitis, psoriasis and eczema etc.

References: Lu ML, et al. Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine. Phytother Res. 2016 Jul; 30(7):1104-12.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	264.36
Molecular Formula	C15H24N2O2
CAS No.	16837-52-8
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 53 mg/mL (200.5 mM)rr
	Water: 53 mg/mL (200.5 mM)rr
	Ethanol: 53 mg/mL (200.5 mM)
Synonyms	Matrine N-oxide; Ammothamnine; Oxysophoridine; Matrine oxide; Matrine 1beta-oxide; Oxymatrine;

Protocol	In Vitro	Oxymatrine is an alkaloid component extracted from the roots of the genus Sophora that has been shown to have anti-inflammatory, anti-fibrotic, anti-tumor, and protective myocardial effects from damage. Potential signaling pathways for oxymatrine may include TGF-β/Smad, toll-like receptor 4/activated B-cytofactor kappa light chain enhancer, toll-like receptor 9/TRAF6, Janus kinase/signal transduction and transcription activator, phosphatidylinositol-3 kinase/Akt, δ-opioid receptor inhibin-Bcl-2, CD40, epidermal growth factor receptor, nuclear factor RBC-2 correlation factor 2/ Heme oxygenase-1 signaling pathway and dimethylarginine dimethylaminohydrolase/asymmetric dimethylarginine metabolic pathway

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.7827 mL	18.9136 mL	37.8272 mL	75.6544 mL
5mM	0.7565 mL	3.7827 mL	7.5654 mL	15.1309 mL
10mM	0.3783 mL	1.8914 mL	3.7827 mL	7.5654 mL
20mM	0.1891 mL	0.9457 mL	1.8914 mL	3.7827 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.