LM11A-31 HCl | CAS 1243259-19-9

LM11A-31 HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$1250	Check With Us
1g	$1950	Check With Us
5g	$5070	Check With Us

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Cat #: V2233 CAS #: 1243259-19-9 Purity ≥ 99%

Description: LM11A-31 HCl，a non-peptide p75NTR (neurotrophin receptor p75) modulator, is an orally active and potent proNGF (nerve growth factor) antagonist，in preventing diabetes-induced BRB breakdown.

References: Elshaer SL, et al. Modulation of the p75 neurotrophin receptor using LM11A-31 prevents diabetes-induced retinalvascular permeability in mice via inhibition of inflammation and the RhoA kinase pathway. Diabetologia. 2019 Aug;62(8):1488-1500.

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Molecular Weight (MW)	316.27
Molecular Formula	C12H27Cl2N3O2
CAS No.	1243259-19-9

Protocol	In Vitro	LM11A-31 (oral gavage; 50 mg kg/day for 4 weeks) significantly mitigates proNGF accumulation and preserves BRB integrity
	Animal model	Male C57BL/6 J mice
	Dosages	50 mg kg/day
	Administration	Oral gavage; for 4 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.1619 mL	15.8093 mL	31.6186 mL	63.2371 mL
5mM	0.6324 mL	3.1619 mL	6.3237 mL	12.6474 mL
10mM	0.3162 mL	1.5809 mL	3.1619 mL	6.3237 mL
20mM	0.1581 mL	0.7905 mL	1.5809 mL	3.1619 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.