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Ropinirole HCl

This product is for research use only, not for human use. We do not sell to patients.

Ropinirole HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$390Check With Us
2g$590Check With Us
5g$890Check With Us
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Cat #: V1265 CAS #: 91374-20-8 Purity ≥ 98%

Description: Ropinirole HCl (formerly SKF 101468; SKF-101468A; SKF 101468A; Requip), the hydrochloride salt of ropinirole, is a potent and selective dopamine D2 receptors agonist ( Ki = 29 nM) of the non-ergoline class of medications used for PD-Parkinson's disease, RLS/restless legs syndrome and extrapyramidal symptoms.

References: Mavrikaki M, et al. Ropinirole regulates emotionality and neuronal activity markers in the limbic forebrain. Int J Neuropsychopharmacol. 2014 Dec;17(12):1981-93.

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Molecular Weight (MW)296.84
Molecular FormulaC16H24N2O.HCl
CAS No.91374-20-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 10 mg/mL (33.7 mM)r
Water: 60 mg/mL (202.1 mM)r
Ethanol: <1 mg/mL
Solubility In VivoChemical Name: 4-[2-(dipropylamino)ethyl]-1,3-dihydroindol-2-one;hydrochloride InChi Key: XDXHAEQXIBQUEZ-UHFFFAOYSA-N InChi Code: InChI=1S/C16H24N2O.ClH/c1-3-9-18(10-4-2)11-8-13-6-5-7-15-14(13)12-16(19)17-15;/h5-7H,3-4,8-12H2,1-2H3,(H,17,19);1H SMILES Code: CCCN(CCC)CCC1=C2CC(=O)NC2=CC=C1.Cl
SynonymsSKF-101468A; Ropinirole Hydrochloride; Ropinirole HCl; UNII-D7ZD41RZI9; SK and F 101468; SK and F-101,468; SKF 101468; SKF101468A; SKF 101468A;
ProtocolIn VitroRopinirole hydrochloride has affinity for D3 receptors of 10-20 fold higher than the D2 and D4 receptors. Ropinirole hydrochloride is weakly active at alpha 2-adrenoceptors and 5-HT2 receptors but inactive at 5-HT1, benzodiazepine and gamma-aminobutyric acid receptors or alpha 1 and beta-adrenoceptors
In VivoRopinirole (0.1-10 mg/kg; i.p.) decreases intracranial self-stimulation (ICSS) thresholds and induces anxiolytic- and antidepressive-like effects without affecting motor activity or spatial memory
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.3688 mL16.8441 mL33.6882 mL67.3764 mL
5mM0.6738 mL3.3688 mL6.7376 mL13.4753 mL
10mM0.3369 mL1.6844 mL3.3688 mL6.7376 mL
20mM0.1684 mL0.8422 mL1.6844 mL3.3688 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.