Domperidone (R33812)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$290	Check With Us
2g	$520	Check With Us
5g	$790	Check With Us

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Cat #: V1262 CAS #: 57808-66-9 Purity ≥ 98%

Description: Domperidone (R 33812; R-33812; KW5338; KW-5338; Motilium; Domperidona) is an orally bioactive dopamine D2 receptor antagonist and an antiemetic medication used to relieve nausea and vomiting.

References: Champion MC, et al. Domperidone, a new dopamine antagonist. CMAJ. 1986;135(5):457-461.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	425.91
Molecular Formula	C22H24ClN5O2
CAS No.	57808-66-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 48 mg/mL (112.7 mM)r
	Water: <1 mg/mLr
	Ethanol: <1 mg/mL
Synonyms	KW 5338; Domperidone; KW5338; KW-5338; Motilium; Domperidona

Protocol	In Vivo	Domperidone acts as both an antiemetic and an upper gastrointestinal tract prokinetic agent. It is rapidly absorbed after oral administration, and few side effects have been reported

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3479 mL	11.7396 mL	23.4791 mL	46.9583 mL
5mM	0.4696 mL	2.3479 mL	4.6958 mL	9.3917 mL
10mM	0.2348 mL	1.1740 mL	2.3479 mL	4.6958 mL
20mM	0.1174 mL	0.5870 mL	1.1740 mL	2.3479 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.