Dopamine HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$150	Check With Us
10g	$250	Check With Us
20g	$375	Check With Us

: [email protected] [email protected]

Cat #: V1269 CAS #: 62-31-7 Purity ≥ 98%

Description: Dopamine HCl (formerly Intropin; Dopamine HCl; ASL 279; ASL279; P 498; 3-Hydroxytyramine, ASL-279 and Intropin), the hydrochloride salt of dopamine, is an endogenous catecholamine neurotransmitter found in a wide variety of animals, it is a dopamine D1-5 receptors agonist.

References: Basu S, et al. The neurotransmitter dopamine inhibits angiogenesis induced by vascular permeability factor/vascular endothelial growth factor. Nat Med. 2001 May;7(5):569-74.

Top Publications Citing Invivochem Products

Product Catalog 2022

Guide to Product Handling

Publications Citing InvivoChem Products

Product Promise

Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	189.64
Molecular Formula	C8H11NO2.HCl
CAS No.	62-31-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 38 mg/mL (200.34mM)r
	Water: 38 mg/mL (200.34mM)r
	Ethanol: <1 mg/mL
Synonyms	ASL-279; Intropin; Dopamine HCl; ASL 279; ASL279; P 498; P-498; P498

Protocol	In Vitro	Vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) strongly stimulates human umbilical vein endothelial cells (HUVECs) proliferation. The stimulatory effect of VPF/VEGF is abrogated by Dopamine (1 µM; 24hours)
	In Vivo	Dopamine (50 mg/kg; i.p. injection; days 1-7) strongly and selectively inhibits the vascular permeabilizing and angiogenic activities of VPF/VEGF
	Animal model	Syngeneic C3Heb/FeJ mice with MOT ascites tumors
	Dosages	50 mg/kg
	Administration	I.p. injection; 7 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	5.2731 mL	26.3657 mL	52.7315 mL	105.4630 mL
5mM	1.0546 mL	5.2731 mL	10.5463 mL	21.0926 mL
10mM	0.5273 mL	2.6366 mL	5.2731 mL	10.5463 mL
20mM	0.2637 mL	1.3183 mL	2.6366 mL	5.2731 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.