Benztropine mesylate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
2g	$200	Check With Us
5g	$350	Check With Us
10g	$525	Check With Us

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Cat #: V1248 CAS #: 132-17-2 Purity ≥ 98%

Description: Benztropine mesylate (NSC-42199; ST-50997629; NSC 42199; ST 50997629; Cogentin; MLS000737056), the mesilate salt of Benztropine, is a highly potent dopamine transporter (DAT) inhibitor used for the treatment of symptoms of Parkinson's disease such as involuntary tremor and dystonia.

References: Jihong Cui, et al. New use of an old drug: inhibition of breast cancer stem cells by benztropine mesylate. Oncotarget. 2017 Jan 3;8(1):1007-1022.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	403.53
Molecular Formula	C21H25NO.CH4SO3
CAS No.	132-17-2
Storage	-20℃ for 3 years in powder formrrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 50 mg/mL (123.9 mM)rrr
	Water: 81 mg/mL (200.7 mM)rrr
	Ethanol: 81 mg/mL (200.7 mM)
Synonyms	NSC42199; ST50997629; NSC-42199; ST-50997629; NSC 42199; ST 50997629; Benzatropine mesylate; Benzotropine mesylate; Benztropine methanesulfonate; Benztropine Mesylate; Cogentin; Cogentin mesylate; MLS000737056

Protocol	In Vitro	Benztropine mesylate (0.1-10 μM; 72 hours) treatment inhibits the cell growth of MDA-MB-231 cells with an IC50 of ~5 μM. In MDA-MB-231 cells and 4T1-luc2 cells, Benztropine mesylate reduces the size as well as the number of mammospheres significantly in a dose-dependent manne
	In Vivo	Benztropine mesylate (1.5 mg/kg; daily; for 3 weeks; Balb/c mice) treatment significantly reduces both tumor size and tumor weight in a 4T1 mouse model
	Animal model	Balb/c mice bearing 4T1 breast tumors
	Dosages	1.5 mg/kg
	Administration	Injection; 3 weeks

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.4781 mL	12.3907 mL	24.7813 mL	49.5626 mL
5mM	0.4956 mL	2.4781 mL	4.9563 mL	9.9125 mL
10mM	0.2478 mL	1.2391 mL	2.4781 mL	4.9563 mL
20mM	0.1239 mL	0.6195 mL	1.2391 mL	2.4781 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.