Pramipexole 2HCl

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$450	Check With Us
1g	$750	Check With Us
5g	$2025	Check With Us

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Cat #: V28566 CAS #: 104632-25-9 Purity ≥ 99%

Description: Pramipexole 2HCl (also known as SND 919), an agonist of the Gαi-linked dopamine receptors D2, D3, and D4, is a potent dopamine agonist of the non-ergoline class that is used for the treatment of Parkinson's disease (PD) and restless legs syndrome (RLS).

References: Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	284.25
Molecular Formula	C10H19Cl2N3S
CAS No.	104632-25-9

Protocol	In Vivo	Pramipexole dihydrochloride (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals. Pramipexole dihydrochloride improves neurological recovery. Pramipexole dihydrochloride prevents ischemic cell death via mitochondrial pathways in ischemic stroke
	Animal model	Male Wistar rats weighing 250-300 g (16-18 weeks old)
	Dosages	0.25 mg/kg, 1 mg/kg
	Administration	Intraperitoneal injection, at 1 hour, 6 hours, 12 hours, 18 hours post-occlusion

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.5180 mL	17.5901 mL	35.1803 mL	70.3606 mL
5mM	0.7036 mL	3.5180 mL	7.0361 mL	14.0721 mL
10mM	0.3518 mL	1.7590 mL	3.5180 mL	7.0361 mL
20mM	0.1759 mL	0.8795 mL	1.7590 mL	3.5180 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.