Clozapine N-oxide

This product is for research use only, not for human use. We do not sell to patients.

Clozapine N-oxide
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Size Price Stock
250mg$850Check With Us
500mg$1350Check With Us
1g$2025Check With Us

Cat #: V9293 CAS #: 34233-69-7 Purity ≥ 98%

Description: Clozapine N-oxide is a metabolite of clozapine (GLXC-06516), activating human muscarinic designer receptors (DREADDs) and suppressing food intake.

References: Wess J, et al. Novel designer receptors to probe GPCR signaling and physiology. Trends Pharmacol Sci. 2013 Jul;34(7):385-92.

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Product Promise

Promise
Molecular Weight (MW)342.82
Molecular FormulaC18H19ClN4O
CAS No.34233-69-7
ProtocolIn VivoAfter a single intraperitoneal (ip) injection of clozapine nitrogen oxide (1 mg/kg) into mice, plasma levels of clozapine nitrogen oxide (CNO) peak at 15 min and are very low after 2 h. Although CNO has a short plasma half-life in mice, the biological effects described after acute treatment of DREADD-expressing laboratory animals are typically much longer (6-10 h)
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9170 mL14.5849 mL29.1698 mL58.3397 mL
5mM0.5834 mL2.9170 mL5.8340 mL11.6679 mL
10mM0.2917 mL1.4585 mL2.9170 mL5.8340 mL
20mM0.1458 mL0.7292 mL1.4585 mL2.9170 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.