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Trimethobenzamide HCl (Ro 2-9578)

This product is for research use only, not for human use. We do not sell to patients.

Trimethobenzamide HCl (Ro 2-9578)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
1g$290Check With Us
2g$520Check With Us
5g$830Check With Us
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Cat #: V2067 CAS #: 554-92-7 Purity ≥ 98%

Description: Trimethobenzamide (also known as Ro 2-9578; trade names Tebamide, Tigan), a blocker of the D2 receptor, is a potent antiemetic that is used to prevent nausea and vomiting.

References: Smith HS, et al. Dopamine receptor antagonists. Ann Palliat Med. 2012 Jul;1(2):137-42.

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Molecular Weight (MW)424.92
Molecular FormulaC21H29ClN2O5
CAS No.554-92-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
ProtocolIn VitroTrimethobenzamide is a (non-phenothiazine) benzamide antiemetic that acts centrally to block D2 receptors, thereby inhibiting the medullary chemoreceptor trigger zone by blocking emetic impulses to the vomiting center
In VivoThe oral bioavailability of Trimethobenzamide is 60% to 100%. The time to peak is about 45 minutes after oral administration and; Intramuscular (I.M.) administration about 30 minutes after intramuscular administration
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.3534 mL11.7669 mL23.5338 mL47.0677 mL
5mM0.4707 mL2.3534 mL4.7068 mL9.4135 mL
10mM0.2353 mL1.1767 mL2.3534 mL4.7068 mL
20mM0.1177 mL0.5883 mL1.1767 mL2.3534 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
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Concentration(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.