Pramipexole 2HCl Monohydrate

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
500mg	$450	Check With Us
1g	$750	Check With Us
5g	$1950	Check With Us

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Cat #: V1261 CAS #: 191217-81-9 Purity ≥ 98%

Description: Pramipexole 2HCl monohydrate (formerly known as SND 919; trade name Mirapex among others) is the dihydrochloride salt and hydrated form of of pramipexole which is a potent agonist of the Gαi-linked dopamine receptors D2, D3, and D4 with neuroprotective effects.

References: Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1; 12(8): dmm033860.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	302.26
Molecular Formula	C10H17N3S.2HCl.H2O
CAS No.	191217-81-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 41 mg/mL (135.6 mM)r
	Water: 60 mg/mL (198.5 mM)r
	Ethanol: <1 mg/mL
Synonyms	SND 919; Pramipexole Dihydrochloride Monohydrate; Pramipexole Dihydrochloride; SND-919; SND919; Pramipexole 2HCl Monohydrate; Pramipexole 2HCl H2O

Protocol	In Vivo	Pramipexole dihydrochloride hydrate (0.25-1 mg/kg; i.p.) significantly reduces the infarction volume in animals
	Animal model	Male Wistar rats weighing 250-300 g (16-18 weeks old)
	Dosages	0.25 mg/kg, 1 mg/kg
	Administration	Intraperitoneal injection

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3084 mL	16.5420 mL	33.0841 mL	66.1682 mL
5mM	0.6617 mL	3.3084 mL	6.6168 mL	13.2336 mL
10mM	0.3308 mL	1.6542 mL	3.3084 mL	6.6168 mL
20mM	0.1654 mL	0.8271 mL	1.6542 mL	3.3084 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.