Metoclopramide HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$250	Check With Us
5g	$450	Check With Us
10g	$675	Check With Us

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Cat #: V1254 CAS #: 7232-21-5 Purity ≥ 98%

Description: Metoclopramide HCl (Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan), the hydrochloride salt of Metoclopramide, is a potent and selective dopamine D2 receptor antagonist used as a medication for treating stomach and esophageal problems such as nausea and vomiting.

References: Bhosale KB, et, al. Dose-dependent response of central dopaminergic systems to metoclopramide in mice. Indian J Exp Biol. 1997 Jun;35(6):618-22.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	336.26
Molecular Formula	C14H23Cl2N3O2
CAS No.	7232-21-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 67 mg/mL (199.3 mM)r
	Water: N/Ar
	Ethanol: 67 mg/mL (199.3 mM)
Synonyms	AHR-3070-C, Metoclopramide HCl, Metoclopramide hydrochloride, Metoclopramide monohydrochloride monohydrate, Maxolon, AHR3070-C, AHR 3070-C, Metozolv, Reglan

Protocol	In Vivo	Metoclopramide (6.7 µg/g; s.c. daily for 50 days) hydrochloride significantly increases the number and the volume of lactotroph cells of the pituitary gland during all phases of the estrous cycle
	Animal model	Adult, virgin female mice of the Swiss EPM-1 strain
	Dosages	6.7 µg/g
	Administration	S.c. daily for 50 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.9739 mL	14.8694 mL	29.7389 mL	59.4778 mL
5mM	0.5948 mL	2.9739 mL	5.9478 mL	11.8956 mL
10mM	0.2974 mL	1.4869 mL	2.9739 mL	5.9478 mL
20mM	0.1487 mL	0.7435 mL	1.4869 mL	2.9739 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.