Xylazine HCl (BAY 1470 HCl)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$450	Check With Us
10g	$650	Check With Us
20g	$975	Check With Us

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Cat #: V1080 CAS #: 23076-35-9 Purity ≥ 98%

Description: Xylazine HCl (Anased; BAY 1470; BAY-1470;Primazine; Rometar; Sedomin; WH-7286; Xilazina), the hydrochloride salt of xylazine and an analogue of clonidine, is an α2-Adrenergic receptor agonist that has been approved as a Veterinarian drug and used for sedation, muscle relaxation, anesthesia, and analgesia in big animals such as horses, cattles and other non-human mammals.

References: Shi XX, et al. Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the CentralNervous System of Rats. PLoS One. 2016 Apr 6;11(4):e0153169.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	256.79
Molecular Formula	C12H16N2S.HCl
CAS No.	23076-35-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 50 mg/mL (194.7 mM)r
	Water: 12 mg/mL (46.73 mM)r
	Ethanol: 50 mg/mL (194.7 mM)
Synonyms	BAY-VA 1470; BAY1470; Anased; BAY 1470; BAY-1470; Xylazine hydrochloride; Primazine; Rometar; Sedomin; WH 7286; Xilazina

Protocol	In Vivo	Xylazine (5.2 mg/kg; intraperitoneal injection; for 10-60 minutes; male Sprague-Dawley rats) administration alters mRNA expression and protein phosphorylation levels of AMPK signaling molecules, suggesting that the LKB1-AMPK pathway plays a role in the sedative and tranquilizing effects in the CNS caused by Xylazine treatment
	Animal model	Male Sprague-Dawley rats (160-180 g)
	Dosages	5.2 mg/kg
	Administration	Intraperitoneal injection; for 10 minutes, 20 minutes, 40 minutes or 60 minutes

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.8942 mL	19.4712 mL	38.9423 mL	77.8847 mL
5mM	0.7788 mL	3.8942 mL	7.7885 mL	15.5769 mL
10mM	0.3894 mL	1.9471 mL	3.8942 mL	7.7885 mL
20mM	0.1947 mL	0.9736 mL	1.9471 mL	3.8942 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.