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Esmolol HCl

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Esmolol HCl
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Size Price Stock
2g$590Check With Us
5g$950Check With Us
10g$1425Check With Us
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Cat #: V1154 CAS #: 81161-17-3 Purity ≥ 98%

Description: Esmolol HCl (Brevibloc; ASL-8052; ASL 8052), the hydrochloride salt of esmolol, is a potent and cardioselective beta-blocker used to control rapid heartbeats or abnormal heart rhythms.

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Molecular Weight (MW)331.83
Molecular FormulaC16H25NO4.HCl
CAS No.81161-17-3
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 66 mg/mL (198.9 mM)r
Water: 66 mg/mL (198.9 mM)r
Ethanol: 66 mg/mL (198.9 mM)
SynonymsASL-8052; Esmolol Hydrochloride; Esmolol HCL; Brevibloc; ASL-8052; Asl 8052; ASL 8052; ASL8052; ASL 8052; Brevibloc; esmolol; esmolol hydrochloride
ProtocolIn VitroEsmolol hydrochloride is the hydrochloride salt form of Esmolol, a short and rapid-acting beta adrenergic antagonist belonging to the class II anti-arrhythmic drugs and devoid of intrinsic sympathomimetic activity. Esmolol hydrochloride competitively blocks beta-1 adrenergic receptors in cardiac muscle and reduces the contractility and cardiac rate of heart muscle, thereby decreasing cardiac output and myocardial oxygen demands. This agent also decreases sympathetic output centrally and blocks renin secretion. At higher doses, Esmolol hydrochloride also blocks beta-2 receptors located in bronchial and vascular smooth muscle, thereby leading to smooth muscle relaxation.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.0136 mL15.0680 mL30.1359 mL60.2718 mL
5mM0.6027 mL3.0136 mL6.0272 mL12.0544 mL
10mM0.3014 mL1.5068 mL3.0136 mL6.0272 mL
20mM0.1507 mL0.7534 mL1.5068 mL3.0136 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
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Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.