Naphazoline HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $350 | Check With Us |
| 100g | $550 | Check With Us |
| 200mg | $825 | Check With Us |
: Cat #: V1117 CAS #: 550-99-2 Purity ≥ 98%
Description: Naphazoline HCl (Albalon Liquifilm; Nafazair; Rhinantin; Vasocon), the hydrochloride salt of Naphazoline, is an imidazoline-based ocular vasoconstrictor and sympathomimetic amine used as a nasal decongestant.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 246.74 |
|---|---|
| Molecular Formula | C14H14N2.HCl |
| CAS No. | 550-99-2 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 17 mg/mL (68.9 mM)rr |
| Water: 49 mg/mL (198.6 mM)rr | |
| Ethanol: 22 mg/mL (89.2 mM) | |
| Synonyms | Albalon Liquifilm; Nafazair; Naphazoline HCl; Rhinantin; Vasocon |
| Protocol | In Vivo | Naphazoline hydrochloride (0.2 mg/kg, 10 µl per eye; IP, once) reduces histamine or antigen-induced conjunctival vascular hyperpermeability in mice, and reduces conjunctivitis in mice via effects on inflammation, NGF and VEGF |
|---|---|---|
| Animal model | Female wild-type BALB/c mice (4-5 weeks, 18 ± 2 g, n=8/group, allergic conjunctivitis mouse model established using histamine or an antigen (ovalbumin)) | |
| Dosages | 0.2 mg/mL, 10 µl per eye | |
| Administration | Intraperitoneal injection (IP), once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0528 mL | 20.2642 mL | 40.5285 mL | 81.0570 mL |
| 5mM | 0.8106 mL | 4.0528 mL | 8.1057 mL | 16.2114 mL |
| 10mM | 0.4053 mL | 2.0264 mL | 4.0528 mL | 8.1057 mL |
| 20mM | 0.2026 mL | 1.0132 mL | 2.0264 mL | 4.0528 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.