Hydroxybupropion
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25mg | $850 | Check With Us |
| 50mg | $1275 | Check With Us |
| 100mg | $1910 | Check With Us |
: Cat #: V40207 CAS #: 92264-81-8 Purity ≥ 99%
Description: Hydroxybupropion is a major metabolite of Bupropion (trade names Wellbutrin and Zyban) which is a marketed antidepressant and a smoking cessation drug.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 255.74 |
|---|---|
| Molecular Formula | C13H18ClNO2 |
| CAS No. | 92264-81-8 |
| Protocol | In Vivo | Plasma levels of Hydroxybupropion greatly exceed those of the parent drug, reaching 10 to 100 times the concentration of Bupropion. Hydroxybupropion shows stronger antitetrabenazine activity (indicative of an antidepressant activity in animals) and has a lower LD50 value than the erythro- and threo- metabolites, suggesting that Hydroxybupropion is the most important active metabolite in vivo for its antidepressant activity. Hydroxybupropion is pharmacologically active, inhibiting norepinephrine and dopamine uptake, and antagonizing nicotine and showing antidepressant effects in rodents |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.9102 mL | 19.5511 mL | 39.1022 mL | 78.2044 mL |
| 5mM | 0.7820 mL | 3.9102 mL | 7.8204 mL | 15.6409 mL |
| 10mM | 0.3910 mL | 1.9551 mL | 3.9102 mL | 7.8204 mL |
| 20mM | 0.1955 mL | 0.9776 mL | 1.9551 mL | 3.9102 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.