Sotalol HCl (MJ 1999)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 2g | $590 | Check With Us |
| 5g | $1150 | Check With Us |
| 10g | $1725 | Check With Us |
: Cat #: V1107 CAS #: 959-24-0 Purity ≥ 98%
Description: Sotalol HCl (Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob), the hydrochloride salt of Sotalol, is a competitive and non-selective β-adrenergic receptor antagonist used to treat and prevent abnormal heart rhythms.
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| Molecular Weight (MW) | 308.82 |
|---|---|
| Molecular Formula | C12H20N2O3S.HCl |
| CAS No. | 959-24-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 62 mg/mL (200.8 mM)r |
| Water: 62 mg/mL (200.8 mM)r | |
| Ethanol: <1 mg/mL | |
| Synonyms | MJ 1999; sotalol Hydrochloride; Sotalol Monohydrochloride; Sotalol HCL; Betapace; Betapace AF; MJ-1999; MJ1999; Sotacor; Darob |
| Protocol | In Vivo | Sotalol hydrochloride (MJ 1999) is an antiarrhythmic agent.Sotalol at doses of up to 100 mg/kg does not affect the electroconvulsive threshold. Applied at doses of 80-100 mg/kg, sotalol hydrochloride does not affect the antielectroshock action of Oxcarbazepine, Lamotrigine, Pregabalin, or Topiramate. Sotalol hydrochloride alone and in combinations with antiepileptics impairs neither motor performance nor long-term memory. Sotalol hydrochloride (100 mg/kg) significantly decreases the brain concentration of Lamotrigine, increases those of Oxcarbazepine and Topiramate, and does not affect the level of Pregabalin |
|---|---|---|
| Animal model | 20-25 g female Swiss mice | |
| Dosages | 100 mg/kg | |
| Administration | Administered intraperitoneally |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.2381 mL | 16.1907 mL | 32.3813 mL | 64.7626 mL |
| 5mM | 0.6476 mL | 3.2381 mL | 6.4763 mL | 12.9525 mL |
| 10mM | 0.3238 mL | 1.6191 mL | 3.2381 mL | 6.4763 mL |
| 20mM | 0.1619 mL | 0.8095 mL | 1.6191 mL | 3.2381 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
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Volume(start)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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V1
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C2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.