Naftopidil 2HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25g | $500 | Check With Us |
| 50g | $800 | Check With Us |
| 100g | $1200 | Check With Us |
: Cat #: V1157 CAS #: 57149-08-3 Purity ≥ 98%
Description: Naftopidil 2HCl (BM-15275; KT-611; BM15275; KT611; Flivas), the dihydrochloride salt of Naftopidil, is a potent and selective α1-adrenergic receptor antagonist with antihypertensive effects.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 465.41 |
|---|---|
| Molecular Formula | C24H28N2O3.2HCl |
| CAS No. | 57149-08-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 41 mg/mL (88.01mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 2 mg/mL (4.23mM) | |
| Solubility In Vivo | 0.5% CMC: 30mg/mL |
| Synonyms | KT-611; BM-15275; KT611; BM 15275; KT 611; BM15275; KT611; Flivas |
| Protocol | In Vitro | Naftopidil dihydrochloride suppresses human prostate tumor growth by altering interactions between tumor cells and stroma |
|---|---|---|
| In Vivo | Naftopidil dihydrochloride (10 mg/kg; p.o; daily; for 28 days) decreases microvessel density (MVD) in E9+PrSC tumors mice model | |
| Animal model | Male athymic mice(7-8 weeks), with E9+PrSC xenograft | |
| Dosages | 10 mg/kg | |
| Administration | Oral administration, daily, for 28 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1486 mL | 10.7432 mL | 21.4864 mL | 42.9729 mL |
| 5mM | 0.4297 mL | 2.1486 mL | 4.2973 mL | 8.5946 mL |
| 10mM | 0.2149 mL | 1.0743 mL | 2.1486 mL | 4.2973 mL |
| 20mM | 0.1074 mL | 0.5372 mL | 1.0743 mL | 2.1486 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.