Clozapine (HF 1854)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$280	Check With Us
10g	$450	Check With Us
20g	$675	Check With Us

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Cat #: V0962 CAS #: 5786-21-0 Purity ≥ 98%

Description: Clozapine (LX 100129; HF1854, LX100129; Leponex; Fazaclo; CLOZARIL; Clozapin; Clozaril) is an atypical antipsychotic drug wand a 5-HT antagonist used in the treatment of schizophrenia.

References: Seeman P, et al. Clozapine, a fast-off-D2 antipsychotic. ACS Chem Neurosci. 2014 Jan 15;5(1):24-9.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	326.82
Molecular Formula	C18H19ClN4
CAS No.	5786-21-0
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 65 mg/mL (198.9 mM)r
	Water: <1 mg/mLr
	Ethanol: 32 mg/mL (97.9 mM)
SMILES Code	CN1CCN(CC1)C2=C3C=CC=CC3=NC4=C(N2)C=C(C=C4)Cl
Synonyms	HF-1854, LX 100-129; HF 1854, LX 100129; HF1854, LX100129; Leponex; Fazaclo; CLOZARIL; Clozapin; Clozaril.

Protocol	In Vitro	Clozapine (HF 1854) is a D2 receptor antagonist with a Ki of 75 nM, blocks the serotonin 5HT2A receptor with a Ki of 4 nM, inhibits the muscarinic M1 receptor with a Ki of 9.5 nM, blocks α2-adrenoceptor with a Ki value of 51 nM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.0598 mL	15.2989 mL	30.5979 mL	61.1958 mL
5mM	0.6120 mL	3.0598 mL	6.1196 mL	12.2392 mL
10mM	0.3060 mL	1.5299 mL	3.0598 mL	6.1196 mL
20mM	0.1530 mL	0.7649 mL	1.5299 mL	3.0598 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.