Vortioxetine (AA21004)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $450 | Check With Us |
| 1g | $700 | Check With Us |
| 5g | $1900 | Check With Us |
: Cat #: V4425 CAS #: 508233-74-7 Purity ≥ 98%
Description: Vortioxetine (Lu-AA21004; Lu-AA-21004; Trintellix and Brintellix) is an approved anti-depressant drug acting as an SSRI (selective serotonin reuptake inhibitor) and serotonin receptor modulator.
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- Related Biological Data
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| Molecular Weight (MW) | 298.45 |
|---|---|
| Molecular Formula | C18H22N2S.HBr |
| CAS No. | 508233-74-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 50 mg/mLr |
| Water:<1 mg/mLr | |
| Ethanol: N/A | |
| Solubility In Vivo | 15% Captisol, pH 9: 10 mg/mL |
| SMILES Code | CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1 |
| Synonyms | LuAA21004, AA-21004; Lu-AA21004, AA21004; Lu AA21004, AA21004, AA 21004; Vortioxetine, vortioxetine hydrobromide, Brintellix |
| Protocol | In Vitro | Vortioxetine (Compound 5m) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine displays antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, agonistic properties at 5-HT1A receptors, and potent inhibition of SERT |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3506 mL | 16.7532 mL | 33.5064 mL | 67.0129 mL |
| 5mM | 0.6701 mL | 3.3506 mL | 6.7013 mL | 13.4026 mL |
| 10mM | 0.3351 mL | 1.6753 mL | 3.3506 mL | 6.7013 mL |
| 20mM | 0.1675 mL | 0.8377 mL | 1.6753 mL | 3.3506 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.