Prucalopride Succinate (R-108512, R-93877)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
2g	$900	Check With Us
5g	$1750	Check With Us
10g	$2625	Check With Us

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Cat #: V0973 CAS #: 179474-85-2 Purity ≥ 98%

Description: Prucalopride (R 108512; R108512; R 108512; trade names: Resolor; Resotran; Motegrity), a novel enterokinetic and benzofuran-based compound, is a novel, selective, high affinity 5-HT (serotonin) receptor agonist for 5-HT4A and 5-HT4B receptor with anti-idiopathic constipation activity.

References: Briejer MR, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.

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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	485.96
Molecular Formula	C18H26ClN3O3.C4H6O4
CAS No.	179474-85-2
Storage	-20℃ for 3 years in powder formrrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 97 mg/mL (199.6 mM)rrr
	Water: 97 mg/mL (199.6 mM)rrr
	Ethanol: <1 mg/mL
SMILES Code	O=C(O)CCC(O)=O.O=C(C1=C(OCC2)C2=C(N)C(Cl)=C1)NC3CCN(CCCOC)CC3
Synonyms	R-108512; R-108512; R108512; Prucalopride Succinate; R 108512; R108512; R 108512; Resolor; Resotran.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0578 mL	10.2889 mL	20.5778 mL	41.1557 mL
5mM	0.4116 mL	2.0578 mL	4.1156 mL	8.2311 mL
10mM	0.2058 mL	1.0289 mL	2.0578 mL	4.1156 mL
20mM	0.1029 mL	0.5144 mL	1.0289 mL	2.0578 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.