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Sertraline HCl

This product is for research use only, not for human use. We do not sell to patients.

Sertraline HCl
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Size Price Stock
5g$480Check With Us
10g$850Check With Us
20g$1275Check With Us
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Cat #: V1029 CAS #: 79559-97-0 Purity ≥ 98%

Description: Sertraline HCl (formerly CP 51,974-1; CP 51974-1; CP-51,974; trade names: Sealdin; Adjuvin; Atruline; Gladem; Tatig; Tresleen; Zoloft), the hydrochloride salt of Sertraline, is a potent and marketed antidepressant drug acting as a 5-HT serotonin receptor antagonist with Ki of 13 nM.

References: Xiang X, et, al. Anti-depressive Effect of Arctiin by Attenuating Neuroinflammation via HMGB1/TLR4- And TNF-α/TNFR1-mediated NF-κB Activation. ACS Chem Neurosci. 2020 Jul 1.

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Molecular Weight (MW)342.69
Molecular FormulaC17H17Cl2N.HCl
CAS No.79559-97-0
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 69 mg/mL (201.3 mM)r
Water: <1 mg/mLr
Ethanol: 15 mg/mL (43.8 mM)
Solubility In Vivo30% PEG400+0.5% Tween80+5% Propylene glycol: 5 mg/mL
SynonymsCP-51974-1 HCl; CP51974-1 HCl; Sertraline Hydrochloride; Sertraline HCl; Sealdin; Adjuvin; Atruline; CP 51,974-1; Cp-51,974-1; CP 51974-1 HCl; CP 51,974; CP51,974; CP-51,974; Gladem; Tatig; Tresleen; Zoloft.
ProtocolIn VitroSertraline (1 μM, 12 hours) inhibits high mobility group box 1 (HMGB1)- or tumor necrosis factor-α (TNF-α)-induced microglial activation and inflammatory mediator production in microglia
In VivoSertraline (10 mg/kg) is shown to produce the optimal anti-depression effectsin chronic unpredictable mild stress (CUMS)-exposed mice
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9181 mL14.5904 mL29.1809 mL58.3618 mL
5mM0.5836 mL2.9181 mL5.8362 mL11.6724 mL
10mM0.2918 mL1.4590 mL2.9181 mL5.8362 mL
20mM0.1459 mL0.7295 mL1.4590 mL2.9181 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.