Vortioxetine (Lu AA21004) HBr

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
1g	$650	Check With Us
2g	$950	Check With Us
5g	$2560	Check With Us

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Cat #: V0970 CAS #: 960203-27-4 Purity ≥ 98%

Description: Vortioxetine HBr (formerly AA21004, Lu-AA21004, AA21004; Lu AA21004), the hydrobromide salt of Vortioxetine which is a marketed and atypical antidepressant, is an orally bioactive and multimodal serotonergic agent with potential anti-depressive activity.

References: Bang-Andersen B, et al. Discovery of 1-[2-(2,4-dimethylphenylsulfanyl)phenyl]piperazine (Lu AA21004): a novel multimodal compound for the treatment of major depressive disorder. J Med Chem. 2011 May 12;54(9):3206-21.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	379.36
Molecular Formula	C18H22N2S.HBr
CAS No.	960203-27-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 76 mg/mL (200.3 mM)r
	Water:<1 mg/mLr
	Ethanol: 17 mg/mL (44.8 mM)
Solubility In Vivo	15% Captisol, pH 9: 10 mg/mL
SMILES Code	CC1=CC=C(SC2=CC=CC=C2N3CCNCC3)C(C)=C1.[H]Br
Synonyms	LuAA21004, AA21004, Lu-AA21004, AA21004; Lu AA21004, AA-21004; AA 21004; Vortioxetine, vortioxetine hydrobromide, Brintellix

Protocol	In Vitro	Vortioxetine (Compound 5m) is a multimodal serotonergic agent, inhibits 5-HT1A, 5-HT1B, 5-HT3A, 5-HT7 receptor and SERT with Ki values of 15 nM, 33 nM, 3.7 nM, 19 nM and 1.6 nM, respectively. Vortioxetine displays antagonistic properties at 5-HT3A and 5-HT7 receptors, partial agonist properties at 5-HT1B receptors, agonistic properties at 5-HT1A receptors, and potent inhibition of SERT

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6360 mL	13.1801 mL	26.3602 mL	52.7204 mL
5mM	0.5272 mL	2.6360 mL	5.2720 mL	10.5441 mL
10mM	0.2636 mL	1.3180 mL	2.6360 mL	5.2720 mL
20mM	0.1318 mL	0.6590 mL	1.3180 mL	2.6360 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.