Loxapine Succinate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $700 | Check With Us |
| 10g | $1250 | Check With Us |
| 20g | $1875 | Check With Us |
: Cat #: V1031 CAS #: 27833-64-3 Purity ≥ 98%
Description: Loxapine Succinate (Loxapac; Adasuve; Cloxazepin; Daxolin; Oxilapine), the succinate salt of Loxapine which is a dibenzoxazepine anti-psychotic drug, is a potent D2DR/D4DR inhibitor as well as serotonergic receptor antagonist.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 445.9 |
|---|---|
| Molecular Formula | C18H18ClN3O.C4H6O4 |
| CAS No. | 27833-64-3 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 89 mg/mL (199.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: 2 mg/mL (4.5 mM) | |
| Synonyms | Loxapac; Cloxazepin; Daxolin; Maleate, Loxipine; Oxilapine |
| Protocol | In Vivo | Loxapine (5 mg/kg; i.p.; daily for 4 or 10 weeks) decreases serotonin (S2) but does not elevate dopamine (D2) receptor numbers in the rat brain |
|---|---|---|
| Animal model | Adult male Wistar rats (150-175 g) | |
| Dosages | 5 mg/kg | |
| Administration | Intraperitoneal injection, daily for 4 or 10 weeks |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2427 mL | 11.2133 mL | 22.4266 mL | 44.8531 mL |
| 5mM | 0.4485 mL | 2.2427 mL | 4.4853 mL | 8.9706 mL |
| 10mM | 0.2243 mL | 1.1213 mL | 2.2427 mL | 4.4853 mL |
| 20mM | 0.1121 mL | 0.5607 mL | 1.1213 mL | 2.2427 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.