LY 344864
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $600 | To Be Confirmed |
| 250mg | $1250 | To Be Confirmed |
| 500mg | $1875 | To Be Confirmed |
: Cat #: V33553 CAS #: 186544-26-3 Purity ≥ 99%
Description: LY-344864 (LY344864) is a novel, potent and selective receptor agonist of 5-HT1F with Ki of 6 nM.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 351.42 |
|---|---|
| Molecular Formula | C21H22FN3O |
| CAS No. | 186544-26-3 |
| Protocol | In Vitro | LY 344864 binds to human 5-HT1F, 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E, 5-HT3A, 5-HT2B, 5-HT2C, 5-HT7, rat α1-adrenergic, rat α2-adrenergic receptors with Kis of 0.006, 0.530, 0.549, 0.575, 1.415, 3.935, 1.695, 3.499, 4.851, 5.06 and 3.69 μM, respectively |
|---|---|---|
| In Vivo | LY 344864 (0-10 ng/kg; p.o. or i.v.; once) inhibits neurogenic dural inflammation in rat migraine pain model. LY 344864 (1 mg/kg; i.v.; once) can cross the blood brain barrier to some extent in rats |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8456 mL | 14.2280 mL | 28.4560 mL | 56.9120 mL |
| 5mM | 0.5691 mL | 2.8456 mL | 5.6912 mL | 11.3824 mL |
| 10mM | 0.2846 mL | 1.4228 mL | 2.8456 mL | 5.6912 mL |
| 20mM | 0.1423 mL | 0.7114 mL | 1.4228 mL | 2.8456 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.