Lu AE58054 (Idalopirdine)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $980 | Check With Us |
| 500mg | $1300 | Check With Us |
| 1g | $1950 | Check With Us |
: Cat #: V3164 CAS #: 467459-31-0 Purity ≥ 98%
Description: Lu AE58054 (also known as Idalopirdine) is potent and selective antagonist of the 5-HT(6) receptor with Ki value of 0.83 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 398.37 |
|---|---|
| Molecular Formula | C₂₀H₁₉F₅N₂O |
| CAS No. | 467459-31-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: >10 mM in DMSOr |
| Water: <1 mg/mLr | |
| Ethanol: | |
| SMILES Code | FC1=CC(NC=C2CCNCC3=CC(OCC(F)(C(F)F)F)=CC=C3)=C2C=C1 |
| Synonyms | Lu AE58054, Idalopirdine) |
| Protocol | In Vivo | Idalopirdine (intraperitoneal injection, 5 mg/kg, daily, 28 days) can reduce food intake and body weight in over-eating rat models |
|---|---|---|
| Animal model | Male Wistar rats | |
| Dosages | Male Wistar rats | |
| Administration | intraperitoneal injection, daily, 28 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5102 mL | 12.5511 mL | 25.1023 mL | 50.2046 mL |
| 5mM | 0.5020 mL | 2.5102 mL | 5.0205 mL | 10.0409 mL |
| 10mM | 0.2510 mL | 1.2551 mL | 2.5102 mL | 5.0205 mL |
| 20mM | 0.1255 mL | 0.6276 mL | 1.2551 mL | 2.5102 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.