PF-04995274
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V27338 CAS #: 1331782-27-4 Purity ≥ 99%
Description: PF-04995274 (PF04995274) is a novel and potent serotonin 4 receptor (5-HT4) partial agonist, acting centrally as a pro-cognitive agent with the potential to be used for the treatment of Alzheimer's disease (AD).
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- Related Biological Data
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| Molecular Weight (MW) | 432.51 |
|---|---|
| Molecular Formula | C23H32N2O6 |
| CAS No. | 1331782-27-4 |
| Protocol | In Vivo | PF-04995274 (3-10 mg/kg; intravenous injection; for 17 days; male 129S6/SvEv mice) treatment results in prophylactic efficacy by attenuating learned fear and decreasing stress-induced depressive-like behavior |
|---|---|---|
| Animal model | Male 129S6/SvEv mice (7-8 weeks) treated with contextual fear conditioning (CFC) and forced swim test (FST) | |
| Dosages | 3 mg/kg, 10 mg/kg | |
| Administration | Intravenous injection; for 17 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3121 mL | 11.5604 mL | 23.1209 mL | 46.2417 mL |
| 5mM | 0.4624 mL | 2.3121 mL | 4.6242 mL | 9.2483 mL |
| 10mM | 0.2312 mL | 1.1560 mL | 2.3121 mL | 4.6242 mL |
| 20mM | 0.1156 mL | 0.5780 mL | 1.1560 mL | 2.3121 mL |
The molarity calculator equation
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Mass
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.