YL-0919
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $849 | Check With Us |
| 500mg | $1280 | Check With Us |
| 1g | $1920 | Check With Us |
: Cat #: V28384 CAS #: 1339058-04-6 Purity ≥ 99%
Description: YL-0919 is a novel, potent and orally bioactive antidepressant acting as 5-HT1A receptor agonist (Ki=0.19 nM) and selective serotonin reuptake inhibitor.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 334.84 |
|---|---|
| Molecular Formula | C18H23ClN2O2 |
| CAS No. | 1339058-04-6 |
| Protocol | In Vitro | Hypidone hydrochloride inhibits the uptake of [3H]-5-HT into rat cerebral cortical synaptosomes and HEK293 cells stably expressing hSERT with IC50 values of 1.78 nM and 1.93,respectively |
|---|---|---|
| In Vivo | Hypidone hydrochloride (YL0919) (oral administration; 1.25 or 5 mg/kg; 4 weeks) and fluoxetine (10 mg/kg) reverses the inhibition of locomotor activity in CUS rats | |
| Animal model | Male ICR mice weighing 18–22 g | |
| Dosages | 1.25, 2.5, and 5 mg/kg | |
| Administration | Oral administration |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.9865 mL | 14.9325 mL | 29.8650 mL | 59.7300 mL |
| 5mM | 0.5973 mL | 2.9865 mL | 5.9730 mL | 11.9460 mL |
| 10mM | 0.2987 mL | 1.4933 mL | 2.9865 mL | 5.9730 mL |
| 20mM | 0.1493 mL | 0.7466 mL | 1.4933 mL | 2.9865 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.