Olanzapine (LY170053)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$299	Check With Us
10g	$480	Check With Us
20g	$720	Check With Us

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Cat #: V0963 CAS #: 132539-06-1 Purity ≥ 98%

Description: Olanzapine (formerly LY-170052, LY 170052, Zyprexa, Zolafren), a thienobenzodiazepine analog, is an approved atypical antipsychotic drug with high affinity for 5-HT2 serotonin and D2 dopamine receptor.

References: Coccurello R, et al. Chronic administration of olanzapine induces metabolic and food intake alterations: a mousemodel of the atypical antipsychotic-associated adverse effects. Psychopharmacology (Berl). 2006 Jul;186(4):561-71.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	312.44
Molecular Formula	C17H20N4S
CAS No.	132539-06-1
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 63 mg/mL (201.6 mM)r
	Water: <1 mg/mLr
	Ethanol: 9 mg/mL (28.8 mM)
SMILES Code	CN1CCN(C2=C(C=C(C)S3)C3=NC4=CC=CC=C4N2)CC1
Synonyms	LY170053; LY-170052, Olanzapine, LY 170052, Zyprexa, Zolafren

Protocol	In Vivo	Olanzapine (0.75, 1.5 and 3 mg/kg) evaluates body weight and periuterine fat mass, as well as insulin, non-esterified fatty acids, triglycerides, and glucose levels in mice
	Animal model	Forty-two, 14, and 28 female CD-1 mice
	Dosages	0.75, 1.5 and 3 mg/kg
	Administration	Orally and chronically administered; 35 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.2006 mL	16.0031 mL	32.0061 mL	64.0123 mL
5mM	0.6401 mL	3.2006 mL	6.4012 mL	12.8025 mL
10mM	0.3201 mL	1.6003 mL	3.2006 mL	6.4012 mL
20mM	0.1600 mL	0.8002 mL	1.6003 mL	3.2006 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.