Home > Signaling Pathways>Neuronal Signaling>5-HT Receptor>GR 127935 HCl
GR 127935 HCl

This product is for research use only, not for human use. We do not sell to patients.

GR 127935 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50mg$950Check With Us
100mg$1550Check With Us
200mg$2325Check With Us
email: [email protected]        [email protected]

Cat #: V21749 CAS #: 148642-42-6 Purity ≥ 98%

Description: GR127935 HCl (GR-127935; GR 127935) is a novel, highly potent and selective 5-HT1B/1D receptor antagonist with pKis of 8.5 for both guinea pig 5-HT1D and rat 5-HT1B receptors.

References: J W Clitherow, et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzanilides as the first selective 5-HT1D antagonists. J Med Chem. 1994 Jul 22;37(15):2253-7.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)534.05
Molecular FormulaC29H32ClN5O3
CAS No.148642-42-6
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8725 mL9.3624 mL18.7248 mL37.4497 mL
5mM0.3745 mL1.8725 mL3.7450 mL7.4899 mL
10mM0.1872 mL0.9362 mL1.8725 mL3.7450 mL
20mM0.0936 mL0.4681 mL0.9362 mL1.8725 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.