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Amitriptyline HCl (Elavil)

This product is for research use only, not for human use. We do not sell to patients.

Amitriptyline HCl (Elavil)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
50g$490Check With Us
100g$850Check With Us
200g$1275Check With Us
email: [email protected]        [email protected]

Cat #: V0992 CAS #: 549-18-8 Purity ≥ 98%

Description: Amitriptyline (Elavil; Tryptanol; Amitriptylin; Damilen; Triptanol), a tricyclic antidepressant (TCA), is an inhibitor of serotonin receptor, norepinephrine receptor, 5-HT4, 5-HT2 and sigma 1 receptor with potential anti-depressive activity.

References: Kim Lawson. A Brief Review of the Pharmacology of Amitriptyline and Clinical Outcomes in Treating Fibromyalgia. Biomedicines. 2017 Jun; 5(2): 24.

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Molecular Weight (MW)313.86
Molecular FormulaC20H23N.HCl
CAS No.549-18-8
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 63 mg/mL (200.7 mM)r
Water: 15 mg/mL (47.8 mM)r
Ethanol: 63 mg/mL (200.7 mM)
Solubility In VivoChemical Name: 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethylpropan-1-amine hydrochloride InChi Key: KFYRPLNVJVHZGT-UHFFFAOYSA-N InChi Code: InChI=1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H SMILES Code: CN(C)CC/C=C1C2=CC=CC=C2CCC3=CC=CC=C13.[H]Cl
Synonymstrade names: Elavil; Amitriptylin; Tryptanol; Damilen; Triptanol; Amitriptyline HCl; Amitriptyline hydrochloride;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM3.1861 mL15.9307 mL31.8613 mL63.7227 mL
5mM0.6372 mL3.1861 mL6.3723 mL12.7445 mL
10mM0.3186 mL1.5931 mL3.1861 mL6.3723 mL
20mM0.1593 mL0.7965 mL1.5931 mL3.1861 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.