Cisapride

This product is for research use only, not for human use. We do not sell to patients.

Cisapride
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
500mg$400Check With Us
1g$650Check With Us
5g$1775Check With Us

Cat #: V11877 CAS #: 81098-60-4 Purity ≥ 99%

Description: Cisapride (formerly R51619; R 51619; R-51619; Kaudalit; Prepulsid; Kinestase; Pridesia; Presid; Propulsid) is a benzamide-based nonselective agonist of serotonin 5-HT4 receptor.

References: Motavallian, A, et al., Does Cisapride, as a 5HT(4) Receptor Agonist, Aggravate the Severity of TNBS-Induced Colitis in Rat. Gastroenterol Res Pract, 2012. 2012: p. 362536.

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Molecular Weight (MW)465.95
Molecular FormulaC23H29ClFN3O4
CAS No.81098-60-4
ProtocolIn VivoCisapride (2 mg/kg, (intraperitoneal); 4 mg/kg, (oral); Once) There were no significant differences in macroscopic features, histopathological features, cytokine profiles, and body weight changes in rats treated with trinitrobenzenesulfonic acid
Animal modelMale Wistar rats with trinitrobenzenesulfonic-acid-(TNBS) induced rat colitis
Dosages2 mg/kg (i.p.); 4 mg/kg, (oral administration)
Administration2 mg/kg, intraperitoneal injection ; 4 mg/kg, oral administration; once
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1462 mL10.7308 mL21.4615 mL42.9231 mL
5mM0.4292 mL2.1462 mL4.2923 mL8.5846 mL
10mM0.2146 mL1.0731 mL2.1462 mL4.2923 mL
20mM0.1073 mL0.5365 mL1.0731 mL2.1462 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.