HJC0350
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $1150 | Check With Us |
| 1g | $1725 | Check With Us |
: Cat #: V1924 CAS #: 885434-70-8 Purity ≥ 98%
Description: HJC0350 is a potent and selective antagonist/inhibitor of EPAC2 with IC50 of 0.3 μM, it exhibited no inhibition on Epac1.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 277.38 |
|---|---|
| Molecular Formula | C15H19NO2S |
| CAS No. | 885434-70-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 52 mg/mL (187.5 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| SMILES Code | O=S(N1C(C)=CC(C)=C1)(C2=C(C)C=C(C)C=C2C)=O |
| Synonyms | HJC 0350; HJC-0350; HJC0350 |
| Protocol | In Vitro | HJC0350 has an apparent IC50 value of 0.3 µM for competing with 8-NBD-cAMP binding of EPAC2, and is about 133-fold more potent than cAMP. HJC0350 is found not to inhibit EPAC1-mediated Rap1-GDP exchange activity at 25 µM in the presence of equal concentration of cAMP, indicating that it is EPAC2-specific antagonists. Pretreatment of HEK293/EPAC2-FL cells with 10 µM HJC0350 fully blocks the 007-AM induced decrease of FRET |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6052 mL | 18.0258 mL | 36.0516 mL | 72.1033 mL |
| 5mM | 0.7210 mL | 3.6052 mL | 7.2103 mL | 14.4207 mL |
| 10mM | 0.3605 mL | 1.8026 mL | 3.6052 mL | 7.2103 mL |
| 20mM | 0.1803 mL | 0.9013 mL | 1.8026 mL | 3.6052 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.