Pemetrexed disodium
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $450 | Check With Us |
| 10g | $650 | Check With Us |
| 20g | $975 | Check With Us |
: Cat #: V0846 CAS #: 150399-23-8 Purity ≥ 98%
Description: Pemetrexed disodium (formerly HSDB-7316; LY-231514; Alimta), the disodium salt of Pemetrexed, is a marketed anticancer drug of the antifolate and antimetabolite class.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 471.37 |
|---|---|
| Molecular Formula | C20H19N5Na2O6 |
| CAS No. | 150399-23-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 94 mg/mL (199.4 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Saline: 30 mg/mL |
| Synonyms | Pemetrexed; LY-231514; LY231514; HSDB-7316; LY 231514; Alimta; HSDB 7316; HSDB7316; ALIMTA. Abbreviation: MTA. |
| Protocol | In Vivo | The group of mice treated with PC61 plus Pemetrexed demonstrates statistically longer survival than other groups. In a survival analysis, significantly better survival is observed in the group of mice treated with PC61 plus Pemetrexed compare with those treated with PC61 alone, rat IgG plus Pemetrexed, or no treatment[ |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1215 mL | 10.6074 mL | 21.2148 mL | 42.4295 mL |
| 5mM | 0.4243 mL | 2.1215 mL | 4.2430 mL | 8.4859 mL |
| 10mM | 0.2121 mL | 1.0607 mL | 2.1215 mL | 4.2430 mL |
| 20mM | 0.1061 mL | 0.5304 mL | 1.0607 mL | 2.1215 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.