Favipiravir (T-705)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $250 | Check With Us |
| 1g | $450 | Check With Us |
| 5g | $1125 | Check With Us |
: Cat #: V1430 CAS #: 259793-96-9 Purity ≥ 98%
Description: Favipiravir (formerly T-705; T705; T 705; Avigan), an approved antiviral drug used to treat influenza in Japan, is a selective RNA-dependent RNA polymerase inhibitor.
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| Molecular Weight (MW) | 157.1 |
|---|---|
| Molecular Formula | C5H4FN3O2 |
| CAS No. | 259793-96-9 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 31 mg/mL (197.3 mM)r |
| Water: 5 mg/mL (31.8 mM)r | |
| Ethanol: 22 mg/mL (140.0 mM) | |
| Synonyms | T705; Avigan; T-705; T 705; 6-Fluoro-3-hydroxy-2-pyrazinecarboxamide |
| Protocol | In Vitro | Favipiravir (T 705) is an antiviral drug that selectively inhibits the RNA-dependent RNA polymerase of influenza virus. Favipiravir (T 705) is a novel antiviral compound that selectively and potently inhibits the RNA-dependent RNA polymerase (RdRP) of influenza and many other RNA viruses. Favipiravir-RTP does not inhibit the human DNA polymerase α, β or γ with IC50>1 mM. The IC50 for the human RNA polymerase II is 905 μM; Favipiravir is therefore 2,650 times more selective for the influenza virus RdRP, consistent with the lack of inhibition of host-cell DNA and RNA synthesis |
|---|---|---|
| In Vivo | Favipiravir (T 705) (30 mg/kg/day, orally) improves survival compare to placebo. Favipiravir (T 705) also provides significant protection against the A/Duck/MN/1525/81(H5N1) virus at a dose of 33 mg/kg/day or more, regardless of the number of daily doses. When given 4 times a day, all mice survive |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 6.3654 mL | 31.8269 mL | 63.6537 mL | 127.3074 mL |
| 5mM | 1.2731 mL | 6.3654 mL | 12.7307 mL | 25.4615 mL |
| 10mM | 0.6365 mL | 3.1827 mL | 6.3654 mL | 12.7307 mL |
| 20mM | 0.3183 mL | 1.5913 mL | 3.1827 mL | 6.3654 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.