Fluorouracil (5-Fluoracil, 5-FU)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 50g | $225 | Check With Us |
| 100g | $400 | Check With Us |
| 200g | $600 | Check With Us |
: Cat #: V1462 CAS #: 51-21-8 Purity ≥ 98%
Description: Fluorouracil (formerly 5-FU; NSC-19893; NSC19893; 5-Fluorouracil), an analogue of uracil, is an approved anticancer medication acting as a potent DNA/RNA synthesis inhibitor.
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- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 130.08 |
|---|---|
| Molecular Formula | C4H3FN2O2 |
| CAS No. | 51-21-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 26 mg/mL (199.9 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | Saline: 10mg/mL |
| Synonyms | NSC 19893; 5-FU; Fluorouracil; NSC-19893; NSC19893; 5-Fluorouracil; Trade name: Adrucil among many others. Chemical Name: 5-fluoropyrimidine-2,4(1H,3H)-dione InChi Key: GHASVSINZRGABV-UHFFFAOYSA-N InChi Code: InChI=1S/C4H3FN2O2/c5-2-1-6-4(9)7-3(2)8/h1H,(H2,6,7,8,9) SMILES Code: O=C1NC(C(F)=CN1)=O |
| Protocol | In Vitro | 5-Fluorouracil (5-Fu) and NSC 123127 (Dox) show synergistic anticancer efficacy. The IC50 value of 5-Fu/Dox-DNM toward human breast cancer (MDA-MB-231) cells is 0.25 μg/mL, presenting an 11.2-fold and 6.1-fold increase in cytotoxicity compared to Dox-DNM and 5-Fu-DNM, respectively |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 7.6876 mL | 38.4379 mL | 76.8758 mL | 153.7515 mL |
| 5mM | 1.5375 mL | 7.6876 mL | 15.3752 mL | 30.7503 mL |
| 10mM | 0.7688 mL | 3.8438 mL | 7.6876 mL | 15.3752 mL |
| 20mM | 0.3844 mL | 1.9219 mL | 3.8438 mL | 7.6876 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.