CCT-251545
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1750 | To Be Confirmed |
| 500mg | $2650 | To Be Confirmed |
| 1g | $3970 | To Be Confirmed |
: Cat #: V5055 CAS #: 1661839-45-7 Purity ≥ 98%
Description: CCT251545 is a novel, potent, selective and orally bioavailable small-molecule inhibitor of WNT signaling with an IC50 of 5 nM in 7dF3 cells.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 421.92 |
|---|---|
| Molecular Formula | C23H24ClN5O |
| CAS No. | 1661839-45-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | CCT251545 potently inhibits WNT pathway activity in COLO205-F1756 clone 4 (an APC -mutant human colorectal cancer cell line engineered to express a modified luciferase-based WNT reporter construct) with an IC50 of 0.035 μM |
|---|---|---|
| In Vivo | CCT251545 (70mg/kg; p.o.; twice daily) causes an inhibition of tumor growth in NCr athymic mice bearing established SW620 human colorectal cancer xenografts | |
| Animal model | 6-8 weeks female NCr athymic mice bearing established SW620 xenografts | |
| Dosages | 70mg/kg | |
| Administration | Oral administration; twice daily; from days 0-7 and days 10-14 |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3701 mL | 11.8506 mL | 23.7012 mL | 47.4024 mL |
| 5mM | 0.4740 mL | 2.3701 mL | 4.7402 mL | 9.4805 mL |
| 10mM | 0.2370 mL | 1.1851 mL | 2.3701 mL | 4.7402 mL |
| 20mM | 0.1185 mL | 0.5925 mL | 1.1851 mL | 2.3701 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.