TAK-243
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V4576 CAS #: 1450833-55-2 Purity ≥ 98%
Description: TAK-243 (also known as MLN-7243; TAK243; AOB-87172) is a novel, potent and selective inhibitor of ubiquitin-like modifier activating enzyme 1 (UBA1; also named as ubiquitin-activating enzyme (UAE)) with potential anticancer activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 519.52 |
|---|---|
| Molecular Formula | C19H20F3N5O5S2 |
| CAS No. | 1450833-55-2 |
| Storage | -20℃ for 3 years in powder formrr |
| -80℃ for 2 years in solvent |
| Protocol | In Vitro | TAK-243 shows anti-proliferative effect on a panel of cell lines derived from hematologic and solid tumors with variable EC50 values that ranged from 0.006 µM to 1.31 µM |
|---|---|---|
| In Vivo | TAK-243 significantly delays tumor growth in mice (T/C=0.02) with no toxicity as evidenced by no changes in mouse body weight, serum chemistry, or organ histology. TAK-243 reduces primary AML tumor burden in both tested samples without toxicity |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9249 mL | 9.6243 mL | 19.2485 mL | 38.4971 mL |
| 5mM | 0.3850 mL | 1.9249 mL | 3.8497 mL | 7.6994 mL |
| 10mM | 0.1925 mL | 0.9624 mL | 1.9249 mL | 3.8497 mL |
| 20mM | 0.0962 mL | 0.4812 mL | 0.9624 mL | 1.9249 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.