ML-792 (ML792) is a novel, potent and specific small ubiquitin-like modifier (SUMO)-activating enzyme (SAE) inhibitor with anticancer activity.

COH000 is an allosteric, covalent and irreversible (covalent) inhibitor of ubiquitin-like 1-activating enzyme (SUMO-activating enzyme) (E1), with an IC50 of 0.2 μM for SUMOylation in vitro.

DKM 2-93 is a covalent and selective inhibitor of the ubiquitin-like modifier activating enzyme 5 (UBA5).

TAK-243 (also known as MLN-7243; TAK243; AOB-87172) is a novel, potent and selective inhibitor of ubiquitin-like modifier activating enzyme 1 (UBA1; also named as ubiquitin-activating enzyme (UAE)) with potential anticancer activity.

PYR-41 is a ubiquitin-activating enzyme inhibitor (UBE1 inhibitor).