S1RA (E-52862) HCI
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1650 | Check With Us |
| 500mg | $2250 | Check With Us |
| 1g | $3375 | Check With Us |
: Cat #: V28975 CAS #: 1265917-14-3 (HCl) Purity ≥ 99%
Description: S1RA HCl (also known as E-52862 HCl) is a potent and selective sigma-1 receptor(σ1R, Ki=17 nM) antagonist, showed good selectivity against σ2R (Ki > 1000 nM).
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 373.881 |
|---|---|
| Molecular Formula | C20H24ClN3O2 |
| CAS No. | 1265917-14-3 (HCl) |
| Synonyms | E-52862 hydrochloride |
| Protocol | In Vitro | S1RA hydrochloride (0.1-10000 nM) has Ki values of 17 and 23.5 nM for σ1R for humans and guinea pigs, respectively |
|---|---|---|
| In Vivo | S1RA hydrochloride (16-80 mg/kg intraperitoneally or 32-128 mg/kg orally; Once) dose-dependent inhibition of formalin-induced pain sensation, capsaicin-induced mechanical hypersensitivity and sciatic nerve injury-induced mechanical and thermal hypersensitivity in mice | |
| Animal model | Male CD1 mice | |
| Dosages | 32, 64, 128 and 160 mg/kg | |
| Administration | Intraperitoneal injection; 32, 64, 128 and 160 mg/kg, once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6746 mL | 13.3732 mL | 26.7465 mL | 53.4930 mL |
| 5mM | 0.5349 mL | 2.6746 mL | 5.3493 mL | 10.6986 mL |
| 10mM | 0.2675 mL | 1.3373 mL | 2.6746 mL | 5.3493 mL |
| 20mM | 0.1337 mL | 0.6687 mL | 1.3373 mL | 2.6746 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.