Vesamicol hydrochloride, (+/-)-
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $350 | To Be Confirmed |
| 500mg | $550 | To Be Confirmed |
| 1g | $825 | To Be Confirmed |
: Cat #: V27982 CAS #: 120447-62-3 Purity ≥ 99%
Description: Vesamicol hydrochloride, (+/-)- [(±)-AH-5183] is a novel and potent inhibitor of acetylcholine transport with a Ki of 2 nM.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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| Molecular Weight (MW) | 295.85 |
|---|---|
| Molecular Formula | C17H26ClNO |
| CAS No. | 120447-62-3 |
| Protocol | In Vitro | The pharmacological actions of (±)-Vesamicol have been attributed to inhibition of acetylcholine transport into synaptic vesicles and the subsequent quantal release of acetylcholine |
|---|---|---|
| In Vivo | (±)-Vesamicol (3 mg/kg; intraperitoneal injection; once; male Wistar rats) treatment increases the levels of cytosolic acetylcholine (ACh) in all regions of the brain, while those of vesicular ACh decreased in all regions except for the striatum | |
| Animal model | Male Wistar rats (120-300 g） | |
| Dosages | 3 mg/kg | |
| Administration | Intraperitoneal injection; once |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.3801 mL | 16.9005 mL | 33.8009 mL | 67.6018 mL |
| 5mM | 0.6760 mL | 3.3801 mL | 6.7602 mL | 13.5204 mL |
| 10mM | 0.3380 mL | 1.6900 mL | 3.3801 mL | 6.7602 mL |
| 20mM | 0.1690 mL | 0.8450 mL | 1.6900 mL | 3.3801 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.