Fluralaner (A1443; AH252723)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$450	Check With Us
500mg	$800	Check With Us
1g	$1200	Check With Us

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Cat #: V5922 CAS #: 864731-61-3 Purity ≥ 98%

Description: Fluralaner (A-1443; AH-252723; trade name: Bravecto) is an orally bioavailable and systemic insecticide and acaricide approved by the US Food and Drug Administration (FDA) under the trade name Bravecto for flea treatment in dogs in May 2014.

References: Williams H, et al. Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in asimulated home environment. Parasit Vectors. 2014 Jun 19;7:275.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	556.2864
Molecular Formula	C22H17Cl2F6N3O3
CAS No.	864731-61-3
SMILES Code	O=C(NCC(NCC(F)(F)F)=O)C1=CC=C(C2=NOC(C(F)(F)F)(C3=CC(Cl)=CC(Cl)=C3)C2)C=C1C
Synonyms	AH252723; A-1443; AH-252723; A1443; AH 252723; A 1443; Fluralaner, trade name: Bravecto.

Protocol	In Vitro	Fluralaner effectively inhibits the reproductive capacity of fleas in vitro. Spawning stops completely at concentrations as low as 25.0 ng/mL. Although no ovicidal effect was observed, Fluralaner exerted larvalicidal effects at very low concentrations (6.25 ng/mL)
Protocol	In Vivo	At each time point measured over a 12-week period in a simulated flea infested environment, flea control for flea control in Fluraner-treated dogs was > 99%. No adverse events were observed in flurana-treated dogs. Even at subinsecticidal concentrations, Fluralaner has complete control over egg laying, larval development, and flea reproduction. In simulated flea infested environments, oral treatment of dogs with flulanel is highly effective for flea elimination

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.7976 mL	8.9882 mL	17.9764 mL	35.9527 mL
5mM	0.3595 mL	1.7976 mL	3.5953 mL	7.1905 mL
10mM	0.1798 mL	0.8988 mL	1.7976 mL	3.5953 mL
20mM	0.0899 mL	0.4494 mL	0.8988 mL	1.7976 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.