Brexpiprazole

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$600	Check With Us
5g	$1650	Check With Us
10g	$2475	Check With Us

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Cat #: V17025 CAS #: 913611-97-9 Purity ≥ 98%

Description: Brexpiprazole (formerly OPC-34712; OPC34712; Rexulti) is a novel D2 dopamine partial agonist [also called serotonin-dopamine activity modulator (SDAM)] approved as an atypical antipsychotic drug.

References: Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	433.57
Molecular Formula	C25H27N3O2S
CAS No.	913611-97-9

Protocol	In Vitro	Brexpiprazole (0-1.0 μM, 4 days) potentiates NGF-induced neurite outgrowth in a dose-dependent manner in PC12 cells
	In Vivo	Brexpiprazole (0-0.1 mg/kg; p.o.; once) improves social recognition deficits in mice
	Animal model	Male C57BL/6NCrSlc mice, Dizocilpine (0.1 mg/kg) (HY-15084B) induced social recognition deficits
	Dosages	0.01, 0.03 and 0.1 mg/kg
	Administration	Oral administration, once

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3064 mL	11.5322 mL	23.0643 mL	46.1287 mL
5mM	0.4613 mL	2.3064 mL	4.6129 mL	9.2257 mL
10mM	0.2306 mL	1.1532 mL	2.3064 mL	4.6129 mL
20mM	0.1153 mL	0.5766 mL	1.1532 mL	2.3064 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.