Olodaterol HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
50mg	$700	Check With Us
100mg	$1250	Check With Us
200mg	$1875	Check With Us

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Cat #: V8325 CAS #: 869477-96-3 Purity ≥ 99%

Description: Olodaterol HCl, the hydrochloride salt of Olodaterol (BI-1744; BI1744; STRIVERDI RESPIMAT), is a ultra-long acting β-adrenergic receptor agonist approved in 2014 as an inhalation for the treatment of patients with chronic obstructive pulmonary disease (COPD).

References: Xing G, et al. Design, synthesis and biological evaluation of 8-(2-amino-1-hydroxyethyl)-6-hydroxy-1,4-benzoxazine-3(4H)-one derivatives as potent β2-adrenoceptor agonists. Bioorg Med Chem. 2020;28(1):115178.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	422.90
Molecular Formula	C21H27ClN2O5
CAS No.	869477-96-3

Protocol	In Vitro	(In Vitro) Olodaterol hydrochloride (0.1~10 nM; fibroblasts) interferes with FGF-induced phosphorylation of signalling cascades
	In Vivo	Olodaterol (1 mg/kg; inhal.; 21 days) accelerats body weights recovery back to control levels (at day 21) and attenuats TGF-β-induced lung fibrosis
	Animal model	Lung fibrosis C57BL/6 mice
	Dosages	1 mg/mL
	Administration	Inhal.; 21 days

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.3646 mL	11.8231 mL	23.6463 mL	47.2925 mL
5mM	0.4729 mL	2.3646 mL	4.7293 mL	9.4585 mL
10mM	0.2365 mL	1.1823 mL	2.3646 mL	4.7293 mL
20mM	0.1182 mL	0.5912 mL	1.1823 mL	2.3646 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.